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Quasi-experiments are achievements that seek to evaluate interventions, however they do not include randomization. They also urge to establish the causal relationship between the symptom and the result. A study was discovered related to semi-experimental study designs, which are known as non-randomized study design, as they are somewhat common in the infectious diseases literature, especially in the field of interventions aimed at reducing the spread of antibiotic-resistant bacteria. Semi-experimental studies are also classified into three types of study designs. A non-control group in semi-experimental research designs, secondly the design of the semi-experimental study without prior testing, thirdly the design of semi-experimental studies with control groups and pre-tests as having the highest level of credibility for assessing causality.It is also often that the intervention is unable to randomly select for the following reasons as ethical considerations, difficulty in randomly arranging patients, inability to randomly arrange sites, and the need for rapid interventions.(MacLehose RR, Reeves BC,et al.2019).
As for the challenges of proving causality when using semi-experimental techniques in infectious disease research. The lack of a randomized task is a fundamental weakness of the quasi-experimental study design. Although the intervention precedes the outcome, the correlation discovered in the experimental similarity satisfies some conditions of causation. Also, the result can be displayed statistically to change with the intervention.(Shadish W 2018).
Interventions A lot of times have a harder time being random to specific places. An example of this is the use of an alcohol-based hand sanitizer on only a small group of healthcare providers. Where this random site design is successful, the sites are often geographically far apart; this raises the question of whether other environmental elements are different, which further complicates the design and research. For the solution that was used, it was rather average, which is the random distribution of different units in the same hospital.(Shadish WR, .2018).
The lack of randomization makes controlling variables seem difficult. For example, in a study aimed at demonstrating that the use of alcohol-based hand sanitizer led to a decrease in the rates of acquisition of antibiotic-resistant bacteria, several potentially significant interferences that may vary between the action before and after (i.e. pre-intervention and post-intervention periods); for variables containing the severity of the disease, the quality of medical care, nursing and antibiotic prescribing practices.( MacLehose RR, Reeves BC,et al.(2019).
The first variant of multivariate regression can also be treated using disease severity assessments, but the confusing second and third variants will be difficult, if not impossible, to identify and manage. (Shadish W2018).
MacLehose RR, Reeves BC, Harvey IM, Sheldon TA, Russell IT, Black AM.(2019). A systematic review of comparisons of effect sizes derived from randomised and non-randomised studies. Health Technol Assess;4(34):1-154. PMID: 11134917.
Shadish WR, Heinsman DT.(2018). Experiments versus quasi-experiments: do they yield the same answer? NIDA Res Monogr.;170:147-64. PMID: 9154256.
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